Download the trial version of "Revo Uninstaller" and see if that works. Select or type the program/driver, hit "uninstall", hit "advanced", hit "scan", then delete what it finds. This will make sure all traces of the program/driver are removed from your system.
If it doesn't work, try booting into "Safe Mode" and then delete it from the directory. I have had to do this in the past to delete drivers.
Worst comes worst, you may have to try it manually in command prompt, but that is a last resort really.
NOTE: Always backup your system before doing actions like this.
Are you uninstalling the driver or just deleting files you think are the driver? You should always use Add or Remove Programs to uninstall.
If you're having problems with the screen mapping of your tablet (the area of your screen your tablet thinks your pen should fit within), contact the tablet maker. They should be able to solve your issue over the phone.
I have uninstalled it through Programs > Uninstall a program. I've only deleted folders that were associated with the program. This file is giving me trouble. And I don't want to re-install the driver without having doubts that the pen for my tablet is still not going to work. So I want this file folder gone.