The advertisers and site owners have no one else to blame but themselves. When you start pushing shit ads that slow down your site, distribute viruses, play sounds, hijack the screen and generally make your site look like a circus on heroine, why are you surprised people start blocking your shit?
I could put up with it if they didn't suck down my processing power so much with bloated flash files, irritate the hell out of me with surprise audio, play audio without even a image to let me know which page it is on, or (the worst) have a great big "download" button on it on a page were I'm trying to download something. I've lost count how many times I've had to trawl through my programs to uninstall the sneaky shit that got access that way.
I ended up getting in a fit of anger and installed Adblock after one of those banner ads with audio scared the fuck out of me. (RIP headphone user?)
I used a computer with no Adblock, and almost every fucking video I loaded had a 30 second ad right before it. When it blatantly gets in the way of my time and Internet usage, then I get pissy. Put them on the fucking side-panels, NOT before my video.