Their layout of buttons are different. But each company produces a model with same specs as the other company, and at the same price. You choose, and stick to it, as Nikon- and Canon lenses are brand specific. None is better, it's a question of habit.
Neither are better. Even in the hands of a top pro they will notice very little, if any, difference in quality between the two brands. Buy into the brand that people you know also use. That way you can share gear and help each other learn.