Well, depending upon what you want to accomplish, the cleanest crispest lines come from paths, infinitely sharp and crisp as a matter of fact. But, that's really only useful for the comics, not for regular line drawings.
For that, I normally draw on paper and scan into PS and convert all the lines into paths. But that's for stylistic reasons as I like to have ragged edges, which is not what you want.
I have a Wacom Bamboo tablet if that makes any difference.