Like Puppy Dangerous said the zoom function is your friend. Work with a larger canvas. I have an Intuous 3 tablet with touch strips which I have set to the zoom function so I can zoom in and out of the image while I'm drawing. You can do the same with hot keys.
I do big canvasses, zoom out so I can see the whole page to do my layout/rough then zoom in to do details. Digital art shouldn't be subject to size restraints except the limit your computer can handle without slowing down.